An Extremely Rare Case of Leukoderma Induced by Cosmetics Containing Ascorbic Acid

An Extremely Rare Case of Leukoderma Induced by Cosmetics Containing Ascorbic Acid

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We report the case of a 73-year-old woman with leukoderma induced by cosmetics containing ascorbic acid.She had noticed the sudden Horse Fleece Quarter Sheets appearance of a hypopigmented macule on the cheek within 1 month after use of the cosmetics with the brand name Obaji C Serum.No history of use of rhododenol-containing cosmetics was declared.Histopathological analysis revealed that the number of matured melanocytes was apparently decreased, and T lymphocytes abundantly U-Base Acrylic LED Night Light infiltrated mainly the perifollicular region.

In addition to the discontinuation of using Obaji C Serum, phototherapy by excimer light was noticeably effective for repigmentation.To our knowledge, there has been no other report so far showing hypopigmented lesions induced by this cosmetic.